Mass Effect 2 werd bekroond tot de beste RPG van dit jaar, evenals de beste Xbox 360-game. God of War 3 werd uitgeroepen tot de beste PlayStation 3-titel, God of War: Ghost of Sparta ging er met de titel 'beste handheld-game' vandoor. Assassin's Creed: Brotherhood mag zich het beste actieavontuur noemen.

De Spike TV Video Game Awards vonden dit jaar plaats op 11  december. De volledige lijst van winnaars is als volgt:

Studio of the Year: BioWare
Best Wii Game: Super Mario Galaxy 2
Best Xbox 360 Game: Mass Effect 2
Best PS3 Game: God of War III
Best PC Game: StarCraft II: Wings of Liberty
Best Handheld Game: God of War: Ghost of Sparta
Best Shooter: Call of Duty: Black Ops
Best Action-Adventure Game: Assassin’s Creed: Brotherhood
Best RPG: Mass Effect 2
Best Multiplayer Game: Halo: Reach
Best Individual Sports Game: Tiger Woods PGA Tour 11
Best Team Sports Game: NBA 2K11
Best Driving Game: Need For Speed: Hot Pursuit
Best Music Game: Rock Band 3
Best Soundtrack: DJ Hero 2
Best Song in a Game: Far Away door José González
Best Original Score: Red Dead Redemption
Best Graphics: God of War III
Best Adapted Video Game: Scott Pilgrim vs. The World: The Game
Best Performance by a Human Male: Neil Patrick Harris als Peter Parker/Amazing Spider-Man
Best Performance by a Human Female: Tricia Helfer als Sarah Kerrigan
Best Downloadable Game: Costume Quest
Best DLC: Red Dead Redemption – Undead Nightmare
Best Independent Game: Limbo
Most Anticipated Game: Portal 2
Game of the Year: Red Dead Redemption